The baby who just was born from many species of the mammal was not born with the effective immunity system. Imunoglobulin protected the baby who just was born from the infection until the immunity system that was owned by them developed. Imunoglobulin was a component from the mechanism of the defence of the natural body. They disintesis in the response to the existence of the particle/the foreign object like the bacteria and the virus. The process of his synthesis was specific for the foreign particle available, that produced a structure immunoglobulin that could know the particle to be foreign and eliminated him from inside the body. Imunoglobulin was found in the high concentration in kolostrum (first milk after the birth) and the low concentration in milk. Apart from imunoglobulin, other proteins that were found in milk that had the activity antimikroba was laktoferin, laktoperoksidase, lisosim, and NAGase. Laktoferin, glikoprotein the iron fastener (ferrum), that was very first was isolated from cattle milk et cetera from ASI. Laktoferin was in large quantities in the mammalian secretion like milk, the tear, saliva, and the liquid seminal, as to several white blood cells.
Laktoferin was one of the minor protein that naturally were in cattle milk in the concentration in general approximately 0.2 gram/litre. In kolostrum, the content laktoferin could be as high as 0,5-1 gram/litre. In HEED and kolostrum mansuia, the concentration laktoferin, was endless, was 2-4 gram/litre and 6-8 gram/litre. In the natural condition, laktoferin only some that tersaturasi with the iron (5-30 percent). Laktoferin had several functions biologik, that is the activity antibakterial/antiinflamatori, the defence towards the infection gastrointestinal, participation in the immunity system sekretori local that bersinergis by several imunoglobulin and other protective protein, was protein antioksidan the iron fastener in the network, and the promotion of the growth of the animal cell like lymphocytes and the cell intestinal. Most micro-organisms needed the iron for the growth and laktoferin had the potential to hinder the growth of the bacteria, and even kill them by hindering the requirement for his iron.
Lisosim had the activity antibakterial against several bacterium. This enzyme usually functions in connection with him with laktoferin and imunoglobulin A (IgA). Lisosim effective against Escherichia coli when co-operating with IgA. Lisosim caused lisis several species salmonellae co-operated with askorbat and peroxide. The two substances were in the concentration that was low in milk. Irradiation microwave could reduce the activity lisosim against E coli. Lisosim could restrict the migration neutrafil in the broken network and possibly functioned as the agency antiinflamatori.3. NAGase
NAGase was the enzyme that had the activity that had implications as an indicator of network damage during mastitis. He was the enzyme lisosomal that was secreted in large quantities to the mammary gland during involusi and inflamasi the enzyme NAGase also was determined to the cattle secretion that was other like the uterus liquid. The specific function NAGase to the mammary gland was not yet known well, but the research indicated that NAGase possibly showed the activity antimikroba. The researcher studied the effect bakterisidal from NAGase to several general pathogen bacterium was found to the cattle uterus, like Actinomyces pyogenes, Stapphycoccus aureus, Streptococcus agalactiae, and Pseudomonas aeruginosa. NAGase hindered this bacteria, but E.coli and Enterobacter aerogenes was not hindered.